(Senior) Scientist, Discovery Pharmacology

Confo Therapeutics is the only GPCR company with a discovery engine that precisely targets desired GPCR conformations. This unique capability allows us to unlock a vast untapped potential for the discovery and development of breakthrough medicines. We are advancing a robust pipeline of large and small molecules focused on validated targets in endocrine and metabolic diseases, as well as addressing a broader array of critical unmet medical needs in collaboration with our partners. Our team of approximately 60 people is dedicated to advancing our technology, expanding our capabilities, and building out our pipeline in order to achieve the best possible therapeutic outcomes for patients.

Confo Therapeutics is located on the Technology Park in Ghent. More information about Confo’s technology and strategy can be found on www.confotherapeutics.com.

For the expansion of our R&D team we are currently looking for a
(Senior) Scientist, Discovery Pharmacology.

This role requires significant expertise in in vivo drug profiling and pharmacokinetics (DMPK) sciences, offering a unique opportunity for the successful candidate to play a pivotal part in discovering and developing new therapeutics for endocrine and metabolic diseases.

Key Responsibilities

• Design, plan, and supervise in vivo PK and preclinical studies promptly to advance drug molecules (small molecule and antibody) across various indications within endocrine and metabolic diseases.

• Develop and lead DMPK, modeling, and simulation strategies to support the progression of drug candidates (small molecule and antibody) from discovery through development.

• Collaborate closely with other departments (biology, chemistry, bioanalysis, screening, clinical development, etc.) and external partners (CROs) to align objectives and produce meaningful DMPK and in vivo efficacy data that guide target validation, compound characterization, and candidate selection.

• Conduct quality control analyses on in vivo and DMPK data generated by CROs.

• Analyze, interpret, and clearly communicate DMPK data, provide expert opinions, and support project decision-making to ensure pipeline progress.

• Stay informed about advances in DMPK research and integrate new concepts as appropriate.

• PhD (or equivalent) in Pharmacology, Biomedical Sciences, or a related field, plus at least four years of industry experience.

• Possess a deep understanding of drug metabolism, distribution, and excretion; experience with both small molecules and antibodies is advantageous.

• Extensive background in preclinical and clinical DMPK in an industrial setting, with a proven record of scientific accomplishments.

• Comprehensive knowledge of ADME sciences, drug metabolism, pharmacokinetics, bioanalysis, PKPD principles, human PK, and familiarity with industry-standard software.

• Experience with various therapeutic modalities is considered a strong asset.

• Outstanding communication and presentation abilities.

• Strong leadership skills, with the capacity to influence others and make decisions.

• Proven ability to work effectively in a matrix environment, manage multiple projects, and handle shifting priorities.